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Nitrogen-containing heterocyclic derivative having 11β-hydroxysteroid dehydrogenase type I inhibitory activity
专利权人:
Takuji Nakatani;Tomoyuki Ogawa;Koji Masuda
发明人:
Koji Masuda,Tomoyuki Ogawa,Takuji Nakatani
申请号:
US12599133
公开号:
US08383622B2
申请日:
2008.05.07
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.A compound represented by the formula:its pharmaceutically acceptable salt, or a solvate thereof,wherein Ring A is a group represented by the formula:Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle,R1 is hydrogen or optionally substituted alkyl,R2 is —OR5, —SR5, halogen, halogenated alkyl or the like,R3 is optionally substituted alkyl or the like,R4 is optionally substituted alkyl or the like,R5 is optionally substituted alkyl or the like,R6 is hydrogen or the like,R7 and R8 are each independently hydrogen or the like,R10 and R11 are each independently hydrogen or the like,R12 is optionally substituted alkyl or the like,m and p are each independently integer of 1 to 3.
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