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Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence of Various Sites
专利权人:
John D. Maynard
发明人:
John D. Maynard,Marwood Neal Ediger,Robert D. Johnson,M. Ries Robinson
申请号:
US13343867
公开号:
US20120179010A1
申请日:
2012.01.05
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue. An illumination system communicates light at a plurality of broadband ranges to an optical probe, which can comprise a flexible probe. Light homogenizers and mode scramblers can be employed in some embodiments. The optical probe can physically contact the tissue, or can be maintained separate from the tissue. The optical probe receives light from the illumination system and transmits it to tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe can communicate the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties.
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