1. A device for delivery of siRNA design through the dermal barrier soderzhascheemikroiglu and a plurality of nanostructures, fabricated on the microneedle surface, wherein the nanostructure forming a predetermined pattern, and design of siRNA for communicating fluid flow with mikroigloy.2. The apparatus of claim 1, wherein the pattern further includes a microstructure wherein the nanostructures have a cross-sectional size smaller than mikrostruktury.3. The apparatus of claim 2, further comprising a second nanostructure sectional size smaller than a cross-sectional microstructures and larger than the first cross-sectional nanostruktur.4. The medical device of claim 1 or 2, wherein at least a portion of nanostructures has a sectional size less than about 500 and greater than about 5 nanometrov.5. The medical device of claim 1 or 2, wherein at least a portion of nanostructures has a spacing between centers of about 50 nanometers to about 1 mikrometra.6. The medical device of claim 1 or 2, wherein at least a portion of nanostructures has a height of about 10 nanometers to about 20 mikrometrov.7. The medical device of claim 1 or 2, wherein at least some portion of the nanostructures have an aspect ratio of from about 0.15 to about 30.8. The apparatus according to claim 1 or 2, wherein the siRNA duplex portion preparation comprises from about 20 to about 30 par.9. The apparatus according to claim 1 or 2, wherein at least one strand of the siRNA comprises a 3-cohesive end of two or three nukleotidov.10. The apparatus according to claim 1 or 2, siRNA preparation comprises additional nucleotides or analogs nukleotidov.11. The apparatus according to claim 1 or 2, wherein the siRNA preparation soda1. Устройство для доставки конструкции киРНК через дермальный барьер, содержащеемикроиглу и множество наноструктур, изготовленных на поверхности микроиглы, где наноструктуры образуют заранее определенный узори конструкцию киРНК, сообщающуюся по потоку текучей среды с микроиглой.2. У
