BARTOLOME-NEBREDA, José,CONDE-CEIDE, Susana,MACDONALD, Gregor,PASTOR-FERNANDEZ, Joaquin,VAN GOOL, Michiel,MARTIN-MARTIN, María,VANHOOF, Greta
申请号：
ES11707172
公开号：
ES2646827T3
申请日:
2011.03.08
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I) ** Formula ** or a stereoisomeric form thereof, wherein R1 is selected from the group consisting of a radical of formula (a-1), (a-2) and (a-3) ； wherein each R6, R7, R8 is independently selected from the group consisting of fluoro； C1-4alkyl； C1-4 alkyloxy； and C1-4 alkyl substituted with 1, 2 or 3 fluorine atoms； R9 is hydrogen or C1-4alkyl； each m1, m2, and m3 is independently selected from 0, 1, 2, 3, and 4； p2 is selected from 1, 2, 3 and 4； each p1 and p3 is independently selected from 1 and 2； or R1 is selected from the group consisting of unsubstituted pyridinyl； pyridinyl substituted with 1 or 2 substituents selected from the group consisting of halogen, C1-4alkyl, trifluoromethyl and C1-4alkyloxy； and unsubstituted tetrahydropyranyl； R2 is selected from the group consisting of hydrogen； C1-4alkyl； trifluoromethyl； C3-8 cycloalkyl； C1-4 alkyloxy； and cyano； R3 is selected from the group consisting of hydrogen； C1-4alkyl； C3-8 cycloalkyl； and C1-4 alkyl substituted with 1, 2 or 3 fluorine atoms； Het is a 5- or 6-membered heterocyclic ring, selected from the group consisting of pyridinyl； pyrimidinyl； pyridazinyl； pyrazinyl； pyrrolyl； oxazolyl； thiazolyl； imidazolyl； pyrazolyl； isothiazolyl； isoxazolyl； oxadiazolyl and triazolyl； R4 is selected from the group consisting of hydrogen； C1-4alkyl； C1-4alkyl substituted with 1, 2 or 3 fluorine atoms； (difluorocyclopropyl) methyl； (cyclopropyl) difluoromethyl； C1-4 hydroxyalkyl； C3-8 cycloalkyl； (C3-8cycloalkyl) -C1-4alkyl； C1-4alkyloxy-C1-6alkyl； C1-4 alkyloxy； C1-4 alkyloxy substituted with 1, 2 or 3 fluorine atoms； (C3-8 cycloalkyl) C1-4alkyloxy； (C1-4alkyloxy-C1-4alkyl) oxy； (C1-4alkyl) -carbonyl； (C1-4alkyl) carbonyl-C1-4alkyl； (cycloalkylC3-8) carbonyl； (C3-8cycloalkyl) -carbonyl-C1-4alkyl； unsubstituted phenyl； phenyl substituted with 1 or 2 substituents selected from the group consisting of halogen, C1-4alkyl, trifluoromethyl, trifluoromethoxy, cyano and C1-4alkyloxy； unsubstituted
