BONNERT, ROGER,LUKER, TIMOTHY,MOHAMMED, RUKHSANA,THOM, STEPHEN,COOK, ANDREW
申请号：
ES06820474
公开号：
ES2380683T3
申请日:
2006.12.12
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula (I) or a pharmaceutically acceptable salt thereof: in which: A and D are independently selected from hydrogen, halogen, phenyl and C1-3 alkyl, the latter being optionally substituted with halogen atoms； E is O, S, NR3 'or CH2； V is halogen, CN or C1-3 alkyl, the latter being optionally substituted with halogen atoms； W is selected from SO2R6 and COR4； X is hydrogen or CF3； Y is selected from O-CR1R2, CR1R2 and CR1R2CR1R2； Z is CONHSO2R6； R1 and R2 independently represent a hydrogen atom, halogen, C3-8 cycloalkyl or a C1-6 alkyl group, the last two groups being optionally substituted with one or more halogen atoms； or R1 and R2 may together form a 3-8 membered ring that optionally contains one or more atoms selected from O, S, NR3 and itself optionally substituted with one or more halogen, C3-8 cycloalkyl or C1-3 alkyl, the last two groups being optionally substituted with one or more halogen or NR4R5； R3 represents hydrogen, C3-8 cycloalkyl or C1-6 alkyl, the last two groups being optionally substituted with halogen atoms； R3 'represents hydrogen, C3-8 cycloalkyl or C1-6 alkyl, the last two groups being optionally substituted with halogen atoms； R4 and R5 independently represent hydrogen, C3-8 cycloalkyl or C1-6 alkyl, the last two groups being optionally substituted with one or more substituents independently selected from halogen, CN, C3-7 cycloalkyl, C1-6 alkyl, OR3 and NR7R8 , aryl, heteroaryl, S (O) nR9 (where n = 0, 1 or 2), CONR7R8, NR3COR10, SO2NR4R5 and NR3SO2R9； or R4 and R5, together with the nitrogen atom to which they are attached, can form a 3-8 membered saturated ring that optionally contains one or more atoms selected from O, N, S (O) n (where n = 0, 1 or 2), NR3 and itself optionally substituted with one or more halogen, OR3, C3-8 cycloalkyl or C1-6 alkyl, the last two groups being optionally substituted with one or more halogens； R 6 represents aryl, heteroaryl, C 3-8 cycloalkyl or C 1-6 alkyl, all of which are optionally subs
