SCHRODER GLAD Sanne (DK),ШРЁДЕР ГЛАД Санне (DK),BIRKEBAEK JENSEN Kim (DK),БИРКЕБЕК ЙЕНСЕН Ким (DK),GRON NORAGER Niels (DK),ГРЁН НЁРАГЕР Нильс (DK),SARVARY Ian (SE),САРВАРИ Ян (SE),VESTERGAARD Mikkel (
申请号：
RU2017104612
公开号：
RU0002734261C2
申请日:
2015.07.31
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: pharmaceuticals.SUBSTANCE: invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, where Y is NR； R is hydrogen or C1-4alkyl； R1 denotes hydrogen, C1-4alkyl or C1-4alkyl substituted with halogen； R2 is halogen； or R and R2 are combined to form condensed 5-member heteroaryl ring, containing 1 nitrogen heteroatom； R3 is selected from a group consisting of hydrogen, halogen, C1-4alkyl, C1-4alkyl substituted with halogen, C1-4alkoxy, C1-4alkoxy substituted with halogen, and oxo； R4a is selected from a group consisting of hydrogen, halogen, -OH, -CN, C1-6alkyl, C1-6alkyl substituted with -C(=O)NR8R9, C1-6alkyl substituted by halogen, C1-C6alkoxy, C1-C6alkoxy substituted with halogen, and 5–6-member heteroaryl containing 1–3 nitrogen heteroatoms； R4b is selected from a group, consisting of hydrogen, halogen, oxo, -OH, C1-4alkyl substituted with halogen, C1-4alkyl, C1-4alkoxy and C1-4alkoxy substituted with halogen； R5 is -(CR8R9)p-CR13R14R15； n, m and p are integers, independently selected from a group consisting of 0, 1 and 2； R6a is selected from a group consisting of hydrogen, C1-6alkyl and C1-6alkyl substituted with hydroxyl； R6b is hydrogen； each R7 independently represents hydrogen or C1-6alkyl； R8 and R9 are independently selected from a group consisting of hydrogen, C1-6alkyl and C1-6alkyl substituted with hydroxyl, a group of di-C1-6alkylamino, -COOH, NH2, C1-6 alkoxy or halogen； R13 is absent or selected from the group consisting of hydrogen, -OH, -CN, halogen, C1-6alkyl, C1-6alkyl substituted with hydroxy, halogen, C1-6alkoxy or -NR8SO2R7, C1-6alkoxy, -(CR8R9)pC(=O)OR7, -(CR8R9)p-SO2R7 and -(CR8R9)pC(=O)NR8R9； R14 and R15 are combined to form a ring system selected from a group consisting of substituted or unsubstituted C3-8cycloalkyl, substituted or unsubstituted C3-7heteroalicylic, containing 1–2 heteroatoms, independently selected from a group consisting of oxygen, nitrogen and optional
