Katerina BISSANTTs (FR),Катерина БИССАНТЦ (FR),Genrietta DEMLOU (DE),Генриетта ДЕМЛОУ (DE),Rajner Eh. MARTIN (CH),Райнер Э. МАРТИН (CH),Ul'rike OBST-ZANDER (CH),Ульрике ОБСТ-ЗАНДЕР (CH),Khans RIKhTER,KATERINA BISSANTTS,Катерина БИССАНТЦ,GENRIETTA DEMLOU,Генриетта ДЕМЛОУ,RAJNER EH. MARTIN,Райнер Э. МАРТИН,ULRIKE OBST-ZANDER,Ульрике ОБСТ-ЗАНДЕР,KHANS RIKHTER,Ханс РИХТЕР,KRISTOF ULLMER,Кристоф УЛЛЬМЕ
申请号：
RU2011120969/04
公开号：
RU0002533887C2
申请日:
2009.10.19
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to new phenylamide or pyridylamide derivatives of formulaor their acceptable salts, wherein A1 is CR12 or N； A2 is CR13 or N； R1 and R2 are independently specified in hydrogen, C1-7-alkyl, halogen and C1-7-alkoxygroup； R12 and R13 are independently specified in hydrogen, C1-7-alkyl, halogen, C1-7-alkoxygroup, amino group and C1-7-alkylsulphanyl； R3 is specified in hydrogen, C1-7-alkyl, halogen, C1-7-alkoxygroup, cyano group, C3-7-cycloalkyl, five-merous heteroaryl and phenyl； R4 is specified in methyl and ethyl； or R3 and R4 together represent -X-(CR14R15)n- and form a part of the ring, wherein X is specified in -CR16R17-, O, S, C=O； R14 and R15 are independently specified in hydrogen or C1-7-alkyl； R16 and R17 are independently specified in hydrogen, C1-7-alkoxycarbonyl, heterocyclyl substituted by two groups specified in a halogen, or R16 and R17 together with an atom C, which they are attached to, form =CH2 group； or X is specified in a group NR18； R14 and R15 are hydrogen； R18 is specified in hydrogen, C1-7-alkyl, halogen-C1-7-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-7-alkyl, heterocyclyl, heteroaryl-C1-7-alkyl, carboxyl-C1-7-alkyl, C1-7-alkoxycarbonyl-C1-7-alkyl, C1-7-alkylcarbonyloxy-C1-7-alkyl, phenyl, wherein phenyl is unsubstituted, phenylcarbonyl, wherein phenyl is substituted by C1-7-alkoxycarbonyl, and phenylsulphonyl, wherein phenyl is substituted by carboxyl-C1-7-alkyl, or R18 and R14 together represent -(CH2)3- and form a part of the ring, or R18 together with R14 and R15 represent -CH=CH-CH= and form a part of the ring； and n has the value of 1, 2 or 3； B1 represents N or CR19 and B2 represents N or CR20, provided no more than one of B1 and B2 represents N； and R19 and R20 are independently specified in a group consisting of hydrogen and halogen-C1-7-alkyl； R5 and R6 are independently specified in a group consisting of hydrogen, halogen and cyano group； and one-three, provided R4 represents
