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Acids 8 - cyano - 1 - 7 - (cyclopropyl - 2.8 - Diazabicyclo - u00ac4.3.0 nonan - 8 - YL) - 6 - Fluoro 1,4 - dihydro - 4 - oxo - quinolino - carboxilicos eventually replaced and its derivatives
专利权人:
BAYER ANIMAL HEALTH GMBH
发明人:
申请号:
NO2011022
公开号:
NO2011022I2
申请日:
2011.10.02
申请国别(地区):
NO
年份:
2013
代理人:
摘要:
The present invention relates to novel optionally substituted 8-cyano-1-cyclo-propyl-7-(2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives, of the general formula (I)in whichR1 represents hydrogen, C1-C4-alkyl which is optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl,R2 represents hydrogen, benzyl, C1-C3-alkyl, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, radicals having the structures -CH=CH-COOR3, -CH2CH2COOR3, -CH2CH2CN, -CH2CH2COCH3 or -CH2COCH3, in which R3 represents methyl or ethyl, or a radical of the general structure R4-(NH-CHR5-CO)n-, in which R4 represents hydrogen, C1-C3-alkyl or the radical -COO-tert-butyl, R5 represents hydrogen, C1-C4-alkyl, hydroxyalkyl, aminoalkyl, thioalkyl, carboxyalkyl or benzyl and n is 1 or 2, andY is oxygen or sulfur,the process for their preparation and their use in antibacterial compositions.
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