Photostabilized pharmaceutical compositions

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专利权人:

Tadao Yamazaki;Tadashi Morikawa;Koichi Takahashi;Masaki Shibata

发明人:

Koichi Takahashi,Tadashi Morikawa,Tadao Yamazaki,Masaki Shibata

申请号：

US13121852

公开号：

US09072791B2

申请日:

2009.09.30

申请国别(地区):

US

年份:

2015

代理人:

摘要：

A crosslinking reaction and a reaction for reducing molecular weight that take place in a hyaluronic acid-methotrexate conjugate upon irradiation with light are suppressed to improve the photostability of the conjugate. Specifically, a substance having a quenching effect and/or a radical scaveng effect is added to a pharmaceutical composition containing the hyaluronic acid-methotrexate conjugate.

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中国工程科技知识中心

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http://www.ckcest.cn/home/