BEBERNITZ, GREGORY RAYMOND,BOCK, MARK G.,REDDY, DUMBALA SRINIVAS,HAJARE, ATUL KASHINATH,VYAVAHARE, VINOD,BHOSALE, SANDEEP BHAUSAHEB,KURHADE, SURESH EKNATH,SALUNKHE, VIDESH,SHAIKH, NADIM S.,BHUNIYA, DE
申请号：
PE0005112012
公开号：
PE12812012A1
申请日:
2010.10.19
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to Glycoside derivative compounds of formula (i) where the ring is an aryl (C6 C10) optionally replaced with Halogen, Nitro, hydroxyl, NS,Among others, the ring a is a Heterocyclic 5 to 7 members it is a link or alquileno (C1 - C6) optionally substituted by Halogen, Hydroxy, among others and it is H, halogen, alkyl (c1-c4),Among others, V is H, X is Halogen, among others [C (r6) - (R7)] T, where R6 and R7 are each h, alkyl (C1 - C6), among others t is 1 to 3 n and q are each of 0 to 3 R1 and A1A are Each h,Alkyl (C1 - C6) (C6 C10), aryl alkyl (c1-c4), among others R2 is Halogen, Hydroxy, CN, alkyl (C1 - C6), among others 2a is OXO, halogen, Nitro, hydroxyl, among others.Preferred compounds are: (2S, 3R, 4R, 5S, 6R) - 2 - [4-chloro-3 - (4 - methyl - 3,4-dihydro - 2H - benzo - [1,4] - oxazin IL - 7 - methyl) phenyl] - 6 - hydroxy - Methyl tetrahydro - piran - 3.4,5 - triol Ethyl Ester of Acid 6 - [2-chloro-5 - ((2S, 3R, 4R, 5S, 6R) - 3,4,5 - trihidroxi - 6 - hydroxy - methyl - 2 - tetrahydro - piran - il) benzyl] - 2,3 dihydro - benzo - [1,4] - oxazin - 4 - carboxylic acid 2 - (6 - [2-chloro-5 - ((2S, 3R, 4R,5S, 6R) - 3,4,5 - trihidroxi - 6 - hydroxy - methyl - 2 - tetrahydro - piran - il) benzyl] - 2,3 dihydro - benzo - [1,4] - oxazin - 4-yl) - ethanone among others.It also relates to a Pharmaceutical Composition and a Crystalline form.These compounds are inhibitors of the co Transporter Sodium D - glucose (SGLT) being useful in the treatment of diabetes, obesity, dyslipidemiaSE REFIERE A COMPUESTOS DERIVADOS DE GLICOSIDO DE FORMULA (I) DONDE EL ANILLO A ES UN ARILO(C6-C10) OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXILO, CN, NITRO, ENTRE OTROS EL ANILLO A ES UN HETEROCICLO DE 5 A 7 MIEMBROS Ya ES UN ENLACE O ALQUILENO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXILO, ENTRE OTROS Y ES H, HALOGENO, ALQUILO(C1-C4), ENTRE OTROS V ES H, HALOGENO, ENTRE OTROS X ES [C(R6)-(R7)]t, EN DONDE R6 Y R7 SON CADA UNO H, ALQUILO(C1-C6), ENTRE OTROS t ES DE 1 A 3 n Y
