The Ergonomic Surgical Instrument Handle described herein is designed to efficiently grasp, maneuver and clamp tissues, objects and vessels within the surgical site. Surgical Instruments with the improved handle are ergonomically designed to be in line with the surgeons wrist and hand as they relate to the surgical site. This novel design makes it easier to maneuver the instrument within the surgical site without awkward angles to the wrist and hand which reduces muscle fatigue and cramping.