The Board of Regents; The University of Texas System
发明人:
Eric N. OLSON,Eva van Rooij
申请号：
US13970379
公开号：
US20140051745A1
申请日:
2013.08.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of cardiomyocytes. Strategies to block expression of the miR-15 family in the heart as a treatment for diverse cardiac disease are provided.
