New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds and application in the synthesis of iv abradine and addition saltsthereof wwith a pharmaceutically acceptable acid
LERESTIF JEAN-MICHEL,LECOUVE JEAN-PIERRE,SOUVIE JEAN-CLAUDE,BRIGOT DANIEL
申请号：
EG2005020086
公开号：
EG25619A
申请日:
2005.02.19
申请国别(地区):
EG
年份:
2012
代理人:
摘要：
Preparation of N-substituted tetrahydro-3-benzazepine derivatives (I) by catalytic hydrogenation of the corresponding dihydro compound (VI) at 40-80[deg]C, then filtering and crystallizing the product. Preparation of N-substituted 3-benzazepine derivatives of formula (I) by catalytic hydrogention of the corresponding dihydro compound of formula (VI) at 40-80[deg]C, then filtering and crystallizing the product. R 1 and R 21-6C linear or branched alkoxy or together complete a 1,3-dioxan or 1,3-dioxolan ring Independent claims are also included for the following: (1) (I) as new compounds； and (2) method for synthesis of ivabradine or its pharmaceutically acceptable salts from (I). [Image].
