MIKKELSEN, Gitte Kobberøe,DAVID, Laurent,WATSON, Stephen,SMITH, Garrick Paul,WILLIAMSON, Douglas Stewart,CHEN, I-Jen
申请号：
ES13815781
公开号：
ES2637170T3
申请日:
2013.12.30
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula A ** Formula ** wherein R1 represents triazolyl or oxadizolyl, said triazolyl or oxadizolyl may optionally be substituted with 1 group R5, X represents N or CH when R1 is triazolyl or when R1 is oxadiazole X represents CH, R5 represents C1-C6 alkyl, C3-C6 cycloalkyl or a 5-6 membered heterocyclic ring with 1 or 2 heteroatom (s) selected from N, O or S, said cycloalkyl or heterocyclic ring is optionally substituted with 1 or 2 C1-C3 alkyls or 1 or 2 C1-C3 alkoxy, R2, R3 and R4 each independently represent hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, O (CH2) nCF3, (CH2) nR6, (C>； = O) R6 or (CH2) n (C>； = O) R6, n>； = 0, 1, 2 or 3, or R2 and R3 or R3 and R4 can form together with the atom to which they are attached a bicyclic heterocyclic ring of 9-10 members with 1 or 2 heteroatom (s) selected from N, O or S, said bicyclic heterocyclic ring may be optionally substituted with 1 or 2 C1-C6 alkyl or 1 or 2 C1-C6 alkoxy, R6 represents a 5-6 membered heterocyclic ring with 1, 2 or 3 heteroatom (s) selected from N, O or S, said heterocyclic ring may be optionally substituted with 1 or 2 C1- alkyl. C3 or 1 or 2 C1-C3 alkoxy, and the pharmaceutically acceptable salts thereof.Un compuesto de Fórmula A**Fórmula** en donde R1 representa triazolilo u oxadizolilo, dicho triazolilo u oxadizolilo puede estar sustituido opcionalmente con 1 grupo R5, X representa N o CH cuando R1 es triazolilo o cuando R1 es oxadiazol X representa CH, R5 representa alquilo C1-C6, cicloalquilo C3-C6 o un anillo heterocíclico de 5-6 miembros con 1 ó 2 heteroátomo(s) seleccionado(s) entre N, O ó S, dicho anillo cicloalquilo o heterocíclico está sustituido opcionalmente con 1 ó 2 alquilos C1-C3 ó 1 ó 2 alcoxi C1-C3, R2, R3 y R4 representan cada uno independientemente hidrógeno, halógeno, alquilo C1-C6, alcoxi C1-C6, O(CH2)nCF3, (CH2)nR6, (C>；=O)R6 o (CH2)n(C>；=O)R6, n >；= 0, 1, 2 ó 3, o R2 y R3 o R3 y R4 pueden formar junto al átomo al que están unidos un anillo heteroc
