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Pyrazolopyrimidine compounds and their use as PDE10 inhibitors
专利权人:
MITSUBISHI TANABE PHARMA CORPORATION
发明人:
KAWANISHI, EIJI,HONGU, MITSUYA,TANAKA, YOSHIHITO
申请号:
ES11747579
公开号:
ES2540867T3
申请日:
2011.02.25
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound represented by the formula [I]: ** Formula ** in which: R 1 is hydrogen, halogen, C 1-6 alkyl or cyano; Ring A is an optionally substituted heterocyclic group, in which the heterocyclic moiety in the "optionally substituted heterocyclic group" represented by Ring A is monocyclic or bicyclic heteroaryl containing 1 to 3 nitrogen atoms as heteroatom or a group having a 5 to 6-membered aliphatic ring fused to it, and in which the "optionally substituted heterocyclic group" represented by ring A is a heterocyclic group optionally substituted with 1 to 6 substituent (s) that are the same or different and selected from the group consisting of C1-6 alkyl; C3-8 cycloalkyl; halogen; halo-C1-5 alkyl; hydroxy; C1-6 alkoxy; C1-5 haloalkoxy; amino optionally substituted with 1 to 2 substituent (s) that are the same or different and selected from C1-6 alkyl and halogen; and cyclic amino optionally substituted with 1 to 3 substituents (s) that are the same or different and selected from C1-6 alkyl and halogen; Ring B is an optionally substituted 3 to 6-membered monocyclic group, in which the unicycle moiety in the "optionally substituted 3 to 6-membered monocyclic group" represented by Ring B is a 4-monocyclic nitrogen-containing heterocyclic group. to 6 members or 3 to 6 member monocyclic hydrocarbon group, and wherein the "optionally substituted 3 to 6 member monocyclic group" represented by ring B is a 3 to 6 member monocyclic group optionally substituted with 1 to 3 substituent (s) that are the same or different and selected from the group consisting of halogen; oxo; hydroxy; C1-6 alkyl optionally substituted with 1 to 2 substituent (s) that are the same or different and selected from hydroxy and C1-6 alkoxy; C1-6 alkoxy; C1-6 alkyl sulfonyloxy; and amino optionally substituted with 1 to 2 substituent (s) that are the same or different and selected from C1-6 alkyl; and Y is represented by the formula [III]: -Z-R2 [III] in which Z is -N (R3) -, -O- or C1-2 alkylene;
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