The present invention provides an anti-human transferrin receptor antibody and an analog thereof, wherein, in the heavy-chain variable region of the antibody, (a) CDR1 comprises the amino acid sequence represented by SEQ ID NO: 62 or SEQ ID NO: 63; (b) CDR2 comprises the amino acid sequence represented by SEQ ID NO: 13 or SEQ ID NO: 14; and (c) CDR3 comprises the amino acid sequence represented by SEQ ID NO: 15 or SEQ ID NO: 16.本發明係提供一種抗人類運鐵蛋白受體抗體及其類似物,該抗體係於重鏈之可變區中,(a)CDR1為包含序列編號62或序列編號63之胺基酸序列而成,(b)CDR2為包含序列編號13或序列編號14之胺基酸序列而成,且(c)CDR3為包含序列編號15或序列編號16之胺基酸序列而成者。