您的位置: 首页 > 农业专利 > 详情页

MÉTODO DE ADMINISTRAÇÃO DE FACTOR VIII SUÍNO SEM DOMÍNIO B
专利权人:
BAXTER INTERNATIONAL INC.;EMORY UNIVERSITY;BAXTER HEALTHCARE SA
发明人:
JOHN S. LOLLAR,GARRETTE E. BERGMAN
申请号:
PT05740319
公开号:
PT1750733E
申请日:
2005.04.28
申请国别(地区):
PT
年份:
2014
代理人:
摘要:
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provide more effective protection to such patients during non-bleeding periods. This invention is based on the discovery that the recombinant B-domainless porcine fVIII, termed OBI-1, has greater bioavailability compared to the natural porcine fVIII partially purified from porcine plasma, termed HYATE:C. Therefore, the inventive method employs lower unit doses of OBI-1, including, alternatively, omission of antibody-neutralizing dosage, or has longer intervals between the administration, compared to HYATE:C, to provide equivalent protection in patients having fVIII deficiency. The invention further provides pharmaceutical compositions and kits containing OBI-1 in combination with a pharmaceutically acceptable carrier, that are useful for treating patients in need of fVIII more effectively.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充