Methods for controlling fucosylation levels in proteins

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专利权人:

BIOCON LIMITED;CENTRO DE INMUNOLOGIA MOLECULAR

发明人:

Pradip Nair,Ramakrishnan Melarkode,Rasika Venkataraman,Laxmi Adhikary,Ankur Bhatnagar,Sunaina Prabhu,Kriti Shukla,Dinesh Baskar,Saravanan Desan,Harish Venkatraman Pai,Jose Enrique Montero Casimiro

申请号：

US14905350

公开号：

US09856502B2

申请日:

2014.07.23

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or a eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/