SEQUENCES USEFUL FOR OBTAINING HIGH LEVEL, COPY NUMBER-DEPENDENT, ESSENTIALLY POSITION-INDEPENDENT GENE EXPRESSION IN CELLULAR AND TRANSGENIC SYSTEMS

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;UNIVERSITY OF WASHINGTON

发明人:

PALMITER, RICHARD, D.,SANDGREN, ERIC, P.,BRINSTER, RALPH, L.

申请号：

WO1993US11595

公开号：

WO9413273(A1)

申请日:

1993.12.03

申请国别(地区):

世界知识产权组织国际局

年份:

1994

代理人:

摘要：

Vertebrate gene locus control regions or a component thereof containing at least one DNaseI hypersensitivity site, when operably linked to a cistron, confer to the cistron essentially tissue-independent, copy number-dependent, position-independent expression. The genes are those expressed in most vertebrate cells, as illustrated by the metallothionein genes.

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