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Azaindoles as respiratory tract fusion virus antiviral agent
专利权人:
JANSSEN R&D IRELAND
发明人:
申请号:
ARP110104742
公开号:
AR084337A1
申请日:
2011.12.16
申请国别(地区):
AR
年份:
2013
代理人:
摘要:
Azaindoles has Inhibitory activity on the replication of RSV and compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.Claim 1: a compound with the formula (1), a prodrug, an n-oxide, by adding a Salt, a Quaternary Amine, a metal ComplexOr one of its estereoquímicamente isomeric forms, where each X is independently or with at least a C N X is n; r1 is present when x = C and R1 is selected from the group of H, Oh, halogenC1 - 6 cycloalkyl alkyl, alkoxy C1 - C3 - 7, 6, N (r6) 2, CO (R7), ch2nh2, CH2OH, NS, C (NH2 = Noh), C (= NH2 noch3), C (= NH) NH2, CF3, ocf3,And B (OH) 2, B (alkyl - or - C1 6) 2; R2 is selected from the group consisting of H, halogen, alkyl, cycloalkyl C1 - C3 - 7, 6, 6 - alkoxy C1,And Co (R7); R3 is - (N - cr8r9 R10); R4 is selected from the group consisting of H, alkyl, cycloalkyl ch2cf3 C1 - C3 - 10, 7, 10 alquenilo C2 - SO2 -, R8,Or a saturated Ring of 4 to 6 members, which contains an oxygen Atom; R5 is present and when it is c, and is selected from the group consisting of H, alkyl, cycloalkyl C1 - C3 - 7, 6, 6 - alkoxy C1,Co (R7), NF3 and Halogen; n is absent when X is R5, R6 is selected from the group consisting of H, alkyl COOCH3 C1 - 6, and conhso2ch3; R7 is selected from the group consisting of Oh.(C1 - 6 or alkyl (alkyl), NH2, nhso2n C1 - 6) 2, nhso2nhch3 (C1, nhso2 alkyl - (6), nhso2 cycloalkyl C3 - 7)(alkyl and N C1 - 6) 2; n is an integer of 1 to 6; R8 and R9 are selected independently from h, alkyl C1 - 10C3 - 7 or cycloalkyl R8 and R9 taken together form an aliphatic Ring of 4 to 6 members that optionally contains a heteroatom selected from Group n, S,Or; R10 is selected from the group consisting of H, alkyl C1 - 6, o, F, cf2h, CN, CF3, conr8r9, coor8, conr8so2r9 (R8), with so2n (r8r9), nr8r9, nr8coor9, ocor8, nr8so2r9, so2nr8r9,So2r8 or a saturated Ring of 4 to 6 members, which contains an oxygen Atom.Azaindoles que tiene actividad inhibitoria sobre la replicación
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