Fischer Christian,Bogen Stephane L.,Childers Matthew L.,Fradera Llinas Francesc Xavier,Kim Alexander J.,Lampe John W.,Machacek Michelle R.,McMasters Daniel R.,Parker, Jr. Dann L.,Sciammetta Nunzio,Shao Pengcheng P.,Sloman David L.,Sun Wanying,Ujjainwalla Feroze,Huang Chunhui
申请号：
US201515532548
公开号：
US10086000(B2)
申请日:
2015.12.01
申请国别(地区):
美国
年份:
2018
代理人:
Zhao Yong`Fitch Catherine D.
摘要：
The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I); wherein A is —C(R1)= or —N═; and X is selected from the group consisting of: (II-i), (II-ii), (I) (II-iii), and (II-iv). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.;
