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NOUVEAUX COMPOSÉS TRICYCLIQUES COMME INHIBITEURS D'ENZYMES IDH MUTANTES
专利权人:
Merck Sharp & Dohme Corp.
发明人:
申请号:
EP15866280.9
公开号:
EP3226690A4
申请日:
2015.12.01
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), (II-ii), (II-iii), and (II-iv). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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