The invention discloses a composition comprising at least one long chain polyunsaturated fatty acid, at least one probiotic and a mixture of oligosaccharides, said mixture containing at least one of lacto-N-neotetraose (LNnT) and lacto-N-tetraose (LNT), at least one N-acetylated oligosaccharide different from LNnT and LNT, at least one sialylated oligosaccharide and at least one neutral oligosaccharide, for use in increasing insulin sensitivity and/or reducing insulin resistance. This composition optionally further comprises 2′-fucosyllactose (FL). This composition is particularly adapted for use in infants who were born preterm and/or who experienced IUGR, in pregnant women suffering from gestational diabetes and in children, adolescents, and adults suffering from insulin resistance and/or type II diabetes.uso de una composición que comprende al menos un ácido graso poliinsaturado de cadena larga (LC-PUFA), al menos un probiótico y una mezcla de oligosacáridos, donde dicha mezcla contiene al menos uno de LNnT, y LNT, al menos un oligosacárido N-acetilado diferente de LNnT y LNT, al menos un oligosacárido sialilado y al menos un oligosacárido neutro como un agente nutricional sintético que es para ser utilizado en el aumento de sensibilidad a la insulina y/o reducción de la resistencia a la insulina.
