The invention discloses a composition comprising at least one long chain polyunsaturated fatty acid at least one probiotic and a mixture of oligosaccharides said mixture containing at least oneof lacto N neotetraose (LNnT) and lacto N tetraose (LNT) at least one N acetylated oligosaccharidedifferent from LNnT and LNT at least one sialylated oligosaccharide and at least one neutral oligosaccharide for use in increasing insulin sensitivity and/or reducing insulin resistance. This compositionoptionally further comprises 2 fucosyllactose (FL). This compositionis particularly adapted for use in infants who were bornpreterm and/or who experienced IUGR in pregnant women suffering from gestational diabetes and in children adolescents and adults suffering from insulin resistance and/or type II diabetes.
