COMPOUNDS AGAINST RALSTONIA PICKETTII FOR APPLICATION IN THE TREATMENT OF RESISTANCE TO INSULIN, AND ALSO THE METHOD FOR DIAGNOSTIC RESISTANCE TO INSULIN
ВАГЕНИНГЕН УНИВЕРСИТЕТ (NL);АКАДЕМИШ МЕДИШ ЦЕНТРУМ (NL)
发明人:
НЬЮВДОРП Макс (NL),ДЕ ВОС Виллем Мейндерт (NL)
申请号：
RU2017102997
公开号：
RU2017102997A
申请日:
2015.08.28
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
Compounds disclosed herein are effective against Ralstonia pickettii for treating or preventing insulin resistance, obesity or type II diabetes of a subject, and include an antibiotic effective against Ralstonia pickettii, an immunogenic compound producing a protective immune response, or an antibody which specifically binds to Ralstonia pickettii or a fragment thereof. In vitro methods for diagnosis or prediction of insulin resistance, obesity or type II diabetes include determining the presence of Ralstonia pickettii or of an antibody which specifically binds to Ralstonia pickettii in a test sample. An antibody binding specifically to an antigen of Ralstonia pickettii, a Ralstonia pickettii cell, or a nucleic acid hybridizing under stringent conditions to a nucleic acid from Ralstonia pickettii is disclosed. A kit including said antibody, the nucleic acid, and optionally a Ralstonia pickettii bacteria or a nucleic acid or protein thereof, a further reagent or a conventional kit component, is also disclosed.
