The invention discloses a composition comprising at least one long chain polyunsaturated fatty acid, at least one probiotic and a mixture of oligosaccharides, said mixture containing at least oneof lacto-N-neotetraose (LNnT) and lacto-N-tetraose (LNT),at least one N-acetylated oligosaccharidedifferent from LNnT and LNT, at least one sialylated oligosaccharide and at least one neutral oligosaccharide, for use in increasing insulin sensitivity and/or reducing insulin resistance. This compositionoptionally further comprises 2-fucosyllactose (FL). This compositionis particularly adapted for use in infants who were bornpreterm and/or who experienced IUGR, in pregnant women suffering from gestational diabetes and in children, adolescents, and adults suffering from insulin resistance and/or type II diabetes.
