您的位置：
首页
>
农业专利
>
详情页
Bicyclic derivatives Inhibitors, i.e., Autotaxin (ATX)
- 专利权人:
- F. HOFFMANN-LA ROCHE AG
- 发明人:
- DANIEL HUNZIKER,JERME HERT,HARALD MAUSER,GUOZHI TANG,LISHA WANG,PATRIZIO MATTEI
- 申请号：
- ARP130103396
- 公开号：
- AR092645A1
- 申请日:
- 2013.09.23
- 申请国别(地区):
- AR
- 年份:
- 2015
- 代理人:
- 摘要：
- Compositions containing the compounds and methods of use of said compounds. Claim 1: Compounds of the formula (1) wherein: R¹ is alkyl, haloalkyl, substituted cycloalkyl, substituted cycloalkylalkyl, substituted piperazinyl, substituted piperidinyl, indanyloxyalkyl, substituted phenyl, substituted phenylalkyl, substituted phenoxyalkyl, substituted phenylcycloalkyl, substituted phenylcycloalkyl, substituted phenylalkyl, substituted pyridinyl, substituted pyridinylalkyl, substituted pyridinylalkyl, substituted pyridinylalkyl, substituted thiophenyl, substituted thiophenylalkyl, substituted thiophenyl alkenyl, substituted thiophenylalkyl, naphthyl,1.1.1.1.1.1. Substituted naftoil, quinollo, substituted isoquinol, substituted isoquinol, substituted 2.3-dihydro-1h-isominol-2-ilo, substituted 1h-indol-2-ilo or benzofuran-2-ilo, substituted cycloquinol, substituted cycloquinol, substituted pyridinol, substituted pyridinediol, substituted isobutyl, substituted isooxybromine, Phenyl substitutes, phenyl substitutes, phenyl substitutes, phenyl substitutes, phenoxy substitutes, phenyl cyclomethane substitutes, phenyl substitutes, pyridine substitutes, pyridine substitutes, pyridine substitutes, pyridine substitutes, thiophosphor substitutes, thiophosphor substitutes1. Substituted thiofluoroalkyl Nile, substituted naftiro, substituted quinine, substituted isoquinol, substituted 2,3-dihydro-1h-isoindol-2-ilo, substituted 1h-indol-2-ilo and substituted benzofuran-2-ilo；R8313 and r183044；This is - oc-No. 8311； - C (o)-C (O) --S (O) -a. Other formulas (2) or (3)；A is -N- or CR⁵-；it is life.- yes.- No. 8310th --C (O) --S (O) --C (o) - No. 8310-o-cr * r8308；R³ and R⁴ are independently selected from H, halogen, alkyl and cycloalkyl； R⁵,R8310a and r8311a were selected independently from h, tar and cyclopentanediol； r831222；R⁹ and R¹⁰ are independently selected from H, alkyl, hydroxyalkyl, haloalkyl, hydroxyhaloalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, cycloalkoxy, cycloalkox
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
