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Derivatives of Benzothiazole antibacterial
专利权人:
ACTELION PHARMACEUTICALS LTD.
发明人:
申请号:
ARP150103754
公开号:
AR102687A1
申请日:
2015.11.18
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
1. Claim 1: a formula compound (1),In the case where R1 is group M, group M is one of the Ma and MB groups represented by the formulas (2) and (3),wherein A represents a bond or C; R¹A is H or halogen; R²A is H or halogen; and R³A is H, C₁₋₃ alkoxy,Oxyhydrogen c833228c83318324;C₁₋₄ hydroxyalkyl,C₂₋₄ dihydroxyalkyl,2-hydroxyacetamide, 1-hydroxymethyl-cycloprop-1-yl, trans-2-hydroxymethyl-cycloprop-1-yl, 3-hydroxyoxetan-3-yl, 3- (hydroxyalkyl C₁₋₃) oxetan-3-yl, 3- aminooxetan-3-yl or 1-aminocycloprop-1-yl; and where R¹B is C₁₋₄ hydroxyalkyl,C₂₋₄ dihydroxyalkyl,C₁₋₄ aminoalkyl,Cquilaalkyl dialkylamino,1-amino-cycloprop-1-yl, 1-hydroxymethyl-cycloprop-1-yl, trans-2-hydroxymethyl-cycloprop-1-yl, trans-2-aminomethyl-cycloprop-1-yl, trans-2-hydroxymethyl- 1-methyl-cycloprop-1-yl, trans-2-hydroxymethyl-2-methyl-cycloprop-1-yl, cis-1-fluoro-2- (hydroxymethyl) cycloprop-1-yl, cis-2-fluoro-2 - (hydroxymethyl) cycloprop-1-yl, 2- (1,2-dihydroxyethyl) -cycloprop-1-yl, 1- (hydroxymethyl) -cyclobutan-1-yl, cis-3- (hydroxymethyl) -1-hydroxy- cyclobutan-1-yl, 3-hydroxyoxetan-3-yl, 3-hydroxyoxetan-3-yl-C₁₋₃ alkyl,3-aminooxetan-3-yl, 3-hydroxymethyl-oxetan-3-yl, trans- (cis-3,4-dihydroxy) -cyclopent-1-yl, 3-hydroxymethylbicyclo [1,1,1] pentan-1- ilo, 4-hydroxytetrahydro-2H-piran-4-yl, (3R, 6S) -3-aminotetrahydro-2H-pyran-6-yl, piperidin-4-yl, 1- (2-hydroxyacetyl) piperidin-4-yl , 3-hydroxyetie-3-yl, 1- (2-hydroxyacetyl) azetidin-3-yl or 1-glycylazetidin-3-yl; or a salt of said compound.Reivindicación 1: Un compuesto de fórmula (1), en donde R¹ es el grupo M, en donde M es uno de los grupos MA y MB representados por las fórmulas (2) y (3), en donde A representa un enlace o CºC; R¹A es H o halógeno; R²A es H o halógeno; y R³A es H, alcoxi C₁₋₃, hidroxialcoxi C₂₋₄, hidroxialquilo C₁₋₄, dihidroxialquilo C₂₋₄, 2-hidroxiacetamido, 1-hidroximetil-cicloprop-1-ilo, trans-2-hidroximetil-cicloprop-1-ilo, 3-hidroxioxetan-3-ilo, 3-(hidroxialquil C₁₋₃)oxetan-3-ilo, 3-aminooxetan-3-ilo o 1-aminociclo
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