Refers to compounds derived from 6,7,8,9 - tetrahydro - 5H - cyclohepta [b] pyridin-3 of formula (i) wherein R1 is H, CN, Halo, alkoxy, among others R2 is piperidinilo or a compound of formula (i), among others, R5, R6, R7, R8 and R9 are each H alquilamino, Hydroxy, alkoxy, among others R10 is H, hydrous I, azido, amino, among others R11 is H, haloalcoxi, alcoxicarbonilo,Among others, phenyl optionally substituted with cn R1 is alkyl, Halo, among others X is o or NH, CH2.Preferred compounds are: 4 - (2 - oxo 2,3 dihydro - 1H imidazo [4,5-b] pyridin-1-yl) piperidin 1 - carboxylate (6R, 9R) - 6 - (2,3 - difluorofenil) - 6 - hydroxy - 2 - oxo - tetrahydro - 5H - cyclohepta 6,7,8,9 [b] pyridin - 9 - ilo 4 - (2 - oxo 2,3 dihydro - 1H imidazo [4,5-b] pyridin-1-yl) piperidin 1 - carboxylate (5S, 6R, 9R) - 6 - (2,3 - di - (4-fluorophenyl) - dihydroxy - 6,7,8,9 - tetrahydro - 5H - cyclohepta [b] pyridin - 9 - ilo among others.It also relates to a Pharmaceutical composition. These compounds are being CGRP Receptor Antagonists useful in the treatment of migrana, Neurogenic inflammation, asthmaSE REFIERE A COMPUESTOS DERIVADOS DE 6,7,8,9-TETRAHIDRO-5H-CICLOHEPTA[b]PIRIDIN DE FORMULA (I) DONDE R1 ES H, CN, HALO, ALCOXI, ENTRE OTROS R2 ES PIPERIDINILO O UN COMPUESTO DE FORMULA (i), ENTRE OTROS R5, R6, R7, R8 Y R9 SON CADA UNO H, HIDROXI, ALCOXI, ALQUILAMINO, ENTRE OTROS R10 ES H, HIDROXI, AZIDO, AMINO, ENTRE OTROS R11 ES H, HALOALCOXI, ALCOXICARBONILO, ENTRE OTROS Ar1 ES FENILO OPCIONALMENTE SUSTITUIDO CON CN, HALO, ALQUILO, ENTRE OTROS X ES O, CH2 O NH. SON COMPUESTOS PREFERIDOS: 4-(2-OXO-2,3-DIHIDRO-1H-IMIDAZO[4,5-b]PIRIDIN-1-IL)PIPERIDIN-1-CARBOXILATO DE (6R,9R)-6-(2,3-DIFLUOROFENIL)-6-HIDROXI-5-OXO-6,7,8,9-TETRAHIDRO-5H-CICLOHEPTA[b]PIRIDIN-9-ILO 4-(2-OXO-2,3-DIHIDRO-1H-IMIDAZO[4,5-b]PIRIDIN-1-IL)PIPERIDIN-1-CARBOXILATO DE (5S,6R,9R)-6-(2,3-DIFLUOROFENIL)-5,6-DIHIDROXI-6,7,8,9-TETRAHIDRO-5H-CICLOHEPTA[b]PIRIDIN-9-ILO ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUT
