Drug synthesis and use Claim 1: a compound selected from formula (1) or its stereoisomer, tautometer or pharmaceutically acceptable salts, wherein X1 is CR1 or N； X2 is CR2 or N； X3 is Cr or N； X1 or X1 is one or two,X2 and X3 are n； Y1 and Y2 are independently selected from CH and N, where Y1 and Y2 are not each n； R1,R2 and R3 were independently selected from h, F, Cl, cn-ch83323；-CH₂CH₃,-CH₂OH, -CH₂F, -CHF₂,-CF8323,-CH CH OH -NH-NHCH₃,-N (CH)-Oh, oc832323,-Ch-8322； - ch8323y-oc8322； - ch-83228oh； r-83088 from h, F, Cl, cn-ch83228oh, - CH (ch8323238a) Oh, - C (ch83232323) 8322； - Oh, - CH (cf832322； - F, - chf832222；-CH₂CHF₂,-CF8323,-C (O) NH-C (O) NHCH-C (O) N (CH)-NH832222,-NHCH₃,-N (CH)-NHC (O) CH-Oh, oc832323,-8 832283；-OCH CH OH -OP (O) (OH)1. Cycloacrylonitrile, cyclopropylmethyl, 1-hydroxypropylacrylonitrile, pyridiene, 3-hydroxy-oxetan-3-ilo, oxetan-3-ilo and azetidin-1-ilo； r8310 was selected from h-ch-832323；-CH₂CH₃,-CH CH OH -CH F -CHF-CF8323,-NH832222,-NHCH₃,-N (CH)-Oh, oc832323,-OCH₂CH₃ and -OCH₂CH₂OH； R⁸ is selected from aryl C₆₋₂₀,carbociclilo CC₂₋₂₀ heterocyclyl,C₁₋₂₀ heteroaryl,- (aril C) - (heterociclilo C)- (C₁₋₂₀ heteroaryl) - (C₂₋₂₀ heterocyclyl),- (heteroaryl C₁₋₂₀) - (heterocyclyl C₂₋₂₀) - (heterocyclyl C₂₋₂₀),- (C₁₋₂₀ heteroaryl) - (C₂₋₂₀ heterocyclyl) - (C₁₋₆ alkyl),- (C₁₋₂₀ heteroaryl) - (C₁₋₆ alkyl) and - (C₁₋₂₀ heteroaryl) -C (= O) - (C₂₋₂₀ heterocyclyl)；Among them, arilo, carboccillo, isopropene and isopropene can be replaced by one or more independent F, Cl, Br, I, CN, - ch-832323 populations；-CH₂CH₃,-CH (CH)-CH CH (CH)-CH₂OH, -CH₂OCH₃,-CH CH OH -C (CH) OH -CH (OH) CH (CH)-C(CH₃)₂CH₂OH, -CH₂CH₂SO₂CH₃,-CH OP (O) (OH)-C (CH) CONH-CH₂OCH₃,-CH CH OH -CH CH OCH-CH₂F, -CHF₂,-CF8323,-CH₂CF₃,-CH₂CHF₂,-CH (CH) CN -C (CH) CN -CH CN -CO H -C (O) CH-CO₂CH₃,-CO C (CH)-COCH (OH) CH-C (O) CH CH-C (O) CH (CH)-C (O) NH-C (O) NHCH-C (O) N (CH)-NH832222,-NHCH₃,-N (CH)-NHC (O) CH-N (CH) COCH-NHS (O) CH-N (CH) C (CH) CON H- (CH) CH CH S (O) CH-No.8322；=O-
