Il-13 producing tr1-like cells and use thereof

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专利权人:

TXCELL

发明人:

FOUSSAT ARNAUD,BASTIAN HERVÉ,BRUN VALÉRIE,QUATANNENS BRIGITTE

申请号：

NZ60508811

公开号：

NZ605088A

申请日:

2011.06.30

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed is an isolated human Tr1 cell population capable of producing IL-13 when activated, wherein said Tr1 cell population secretes an amount of IL-13 of more than 10ng/ml. Also disclosed is an in vitro method of identifying said human Tr1 cell population, comprising: - detecting the cell surface expression of CD4, and at least one of CD127 and CD62L markers on a cell population, - detecting the production of IL-13, or IL13 and IL-10, wherein the cells expressing CD4 and a low level of CD127 and/or a low level CD62L and producing 1) more than 10ng/mL IL-13 when activated or 2) IL-10 and more than 10ng/mL IL-13 when activated, are the IL-13 producing Tr1 cell population.

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