MASH DEBORAH C.,MORIARTY ROBERT M.,GLESS RICHARD D.
申请号：
NZ61436612
公开号：
NZ614366A
申请日:
2012.01.23
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
The disclosure relates to a method for preparing and purifying noribogaine which method comprises: (a) covalently attaching voacangine to a solid support via the indole nitrogen of voacangine so as to form a suspension of solid supports having voacangine bound thereto； (b) converting voacangine to 12-hydroxyibogamine-18-carboxylic acid methyl ester, 12-hydroxyibogamine-18-carboxylic acid or the carboxylic acid salt thereof under conditions wherein the level of voacangine bound to the solid support is less than 0.1 weight percent； (c) cleaving and recovering 12-hydroxyibogamine-18-carboxylic acid methyl ester, 12-hydroxyibogamine-18-carboxylic acid or the carboxylic acid salt thereof from the solid support； (d) converting the 12-hydroxyibogamine-18-carboxylic acid methyl ester, 12-hydroxyibogamine-18-carboxylic acid or the carboxylic acid salt thereof to noribogaine； and (e) isolating and purifying noribogaine.
