HYBRID PROTEIN THAT CONVERTS ARACHIDONIC ACID INTO PROSTACYCLIN

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专利权人:

发明人:

Ke-He RUAN

申请号：

US14885561

公开号：

US20160114005A1

申请日:

2015.10.16

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A recombinant 130-kDa protein is constructed by linking together human cyclooxygenase (COX) isoform-2 (COX-2) and prostacyclin synthase (PGIS), via a 10-20 amino acid residues of a transmembrane sequence. The engineered protein is expressed in cells, and adopts the functions of COX and PGIS, to continually convert arachidonic acid (AA) into prostaglandin G2 (catalytic step 1), prostaglandin H2 (catalytic step 2) and prostacyclin (PGI2 catalytic step 3).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/