Disclosed in certain embodiments is an immediate release solid oral dosage form comprising a plurality of particles, each particle comprising: (i) a core comprising a first active agent； (ii) a coating comprising a second active agent layered over the core； and (iii) a material that is sensitive to acidic pH layered over the coated core； wherein the dosage form releases at least about 70% of the second active agent within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml 0.1N HCl at 37℃.本發明在某些實施態樣中揭示一種立即釋出型固體口服劑型，其包含複數個粒子，各粒子包含：(i)包含第一活性劑之核心，(ii)包含層疊於該核心上之第二活性劑之塗層，及(iii)層疊於該塗層核心上之對酸性pH敏感之材料，其中藉由美國藥典設備2(槳式)在37℃下500ml 0.1N HCl中以50rpm進行活體外溶離試驗測量，該劑型於45分鐘內釋出至少約70%之該第二活性劑。
