As this invention suppresses the advance of nervous dysfunction chronic progression of the parkinsons disease by conservation obstruction or the dopamin neurocyte from the pathogenesis, extends the period to L-dopa taking time it designates that the medicine which possesses the functional improvement effect is offered as topic. As for this invention, general expression (1)< Conversion 1 >[In formula, R shows hydrogen and the like. R shows hydrogen and the like. 3R shows the phenyl group and the like which is possible to have possessed the substituent. R shows hydrogen and the like. R shows hydrogen and the like. R shows hydrogen and the like. R shows the hydroxy basis and the like. ]So the medicine which includes quinolone chemical compound or that salt which is displayed is offered.本発明は、パーキンソン病の慢性進行性を阻止もしくはドパミン神経細胞をその病因から保護することにより神経機能障害の進行を抑制し、L-ドーパ服用時期までの期間を延長すると共に機能改善効果を有する薬剤を提供することを課題とする。本発明は、一般式(1)【化1】[式中、R1は、水素等を示す。R2は、水素等を示す。R3は、置換基を有していてもよいフェニル基等を示す。R4は、水素等を示す。R5は水素等を示す。R6は、水素等を示す。R7は、ヒドロキシ基等を示す。]で表されるキノロン化合物又はその塩を含む薬剤を提供する。
