The present disclosure provides a fermentation product of Punica granatum and a use of the fermentation product of Punica granatum for regulating expression of MMP gene, TIMP gene and COL4A4 gene, promoting collagen production, and anti-aging.本發明提供一種石榴發酵物及其用於調控MMP基因、TIMP基因、及COL4A4基因的表現量、促進膠原蛋白產生及抗老化的用途。