DRESCHER, KARLA,HAUPT, ANDREAS,UNGER, LILIANE,TURNER, SEAN C.,BRAJE, WILFRIED,GRANDEL, ROLAN
申请号：
CA2583967
公开号：
CA2583967C
申请日:
2005.10.14
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to 6-amino(aza)indane compound of the formula(I) Wherein Ar is phenyl or an aromatic 5- or 6-membered C-boundheteroaromatic radical, wherein Ar may carry 1 radical Ra and wherein Ar mayalso carry I or 2 radicals Rb； X is N or CH； E is CR6R7 or NR 3； R1 is C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl,fluorinated C3-C4-alkenyl, formyl or C1-C3-alkylcarbonyl； R1a is H or R1a andR2 or R1a and R2a together are (CH2)n with n being 1, 2, 3 or 4； R2 and R2aeach independently are H, CH3, CH2F, CHF2 or CF3； R3 is H or C,-C4-alkyl； andthe physiologically tolerated acid addition salts of these compounds. Theinvention also relates to pharmaceutical compositions comprising at least onecompound of the formula (I) or a pharmaceutically acceptable salt thereof andto a method for treating a medical disorder susceptible to treatment with adopamine D3 receptor ligand, said method comprising administering an effectiveamount of at least one compound of the formula (I) or a pharmaceuticallyacceptable salt thereof.
