Andreas Kling;Helmut Mack;Volker Nimmrich;Achim Moeller;Wilfried Hornberger;Dietmar Seeman;Wilfried Lubisch
发明人:
Andreas Kling,Wilfried Hornberger,Helmut Mack,Achim Moeller,Volker Nimmrich,Dietmar Seeman,Wilfried Lubisch
申请号：
US11990652
公开号：
US08436034B2
申请日:
2007.12.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.The carboxamide compounds are compounds of the general formula Iin which R1, R2, R3a, R3b, W, Y and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a′ and I-A.a″in which m, E, R1, R3a, R3b, R2, Ry, Rw and Rw6* have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.
