Moeller, Achim,Kling, Andreas,Seemann, Dietmar,Lubisch, Wilfried,Nimmrich, Volker,Hornberger, Wilfried,Mack, Helmut
申请号：
AU2013200138
公开号：
AU2013200138A1
申请日:
2013.01.11
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013200138A120130131.pdf#####CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS ABSTRACT The present invention relates to.novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R R2, Ra , R3b, W, Y and X have the meanings mentioned in the claims and 15 the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula IA.a and I-A.a" in which m, E, R, R , R, R2 , RY, Rw and Rw6 * have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof. (R )n R N 0 R I I2H XN R 3 (I-A.a) R-W-Y N ( N N1 3b 3a R2 HR R (RW,)m H R R 1 (R)n O R x N H R 6 N N \ (-A a") N:: E (R" )m
