MACK, HELMUT,KLING, ANDREAS,JANTOS, KATJA,MOELLER, ACHIM,HORNBERGER, WILFRIED,HUTCHINS, CHARLES, W
申请号：
NZ59600010
公开号：
NZ596000A
申请日:
2010.05.06
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
596000 Disclosed herein are carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R1, R2, R3a, R3b, R4, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula (Ia) and (Ib) in which R1, r, R2b, R3a, R3b, R4, Y and X have the meanings mentioned in the claims, including the tautomers thereof and the pharmaceutically suitable salts thereof.
