Федеральное государственное бюджетное учреждение "Научный центр сердечно-сосудистой хирургии имени А.Н. Бакулева" Российской академии медицинских наук (RU)
发明人:
Бокерия Леонид Антонович (RU),Новикова Светлана Петровна (RU)
申请号：
RU2012134520/15
公开号：
RU2012134520A
申请日:
2012.08.13
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. bioresorbable hydrogel polymeric compositions comprising natural polymers, biologically active substance, solvent and plasticizer, characterized in that the crosslinked polymers are bioresorbable polymers or mixtures thereof, which are used as proteins - gelatin, polysaccharides - chitosan and its derivatives, polyesters - polyhydroxybutyrate, and as biologically active compounds or mixtures thereof are used antioxidants, and / or anticoagulant and / or antiplatelet agents, and / or a non-steroidal antiinflammatory exists, and / or anti-microbial agents, and as antioxidants used peptides-L-carnosine, as anticoagulants - heparin, as antiplatelet agents - dipyridamole, acetyl salicylic acid, as nonsteroidal antiinflammatory agents - acetylsalicylic acid as antimicrobials - ciprofloxacin, metronidazol.2. A composition according to claim 1, characterized in that the amount of biologically active substances to the composition: 3. A composition according to claim 1, characterized in that the total amount of polymers or their mixtures with biologically active substances must be such that the mechanical strength of the film was not less than 1.2 MPa, elongation - not more than 160% modulus - 0.4 -5 MPa.4. A composition according to claim 1, characterized in that the joint use of chitosan and gelatin, the gelatin in the composition should be at least 20% .5. A composition according to claim 1, characterized in that the joint use of chitosan and polyhydroxybutyrate, polyhydroxybutyrate in the composition should be no more than 30% .6. A composition according to claim 1, characterized in that as cross-linking and1. Биорезорбируемые гидрогелевые полимерные композиции, включающие природные полимеры, биологически активные вещества, растворитель и пластификатор, отличающиеся тем, что в качестве полимеров используют сшитые биорезорбируемые полимеры или их смеси, в качестве которых используют белки - желатин, полисахариды - хитозан и его производные, полиэфиры - полигидроксибутир
