Kaplan, David L.,Panilaitis, Bruce,Pritchard, Eleanor M.,Omenetto, Fiorenzo
申请号：
AU2018267539
公开号：
AU2018267539A1
申请日:
2018.11.19
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018267539A120181213.pdf#####The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making antibiotic-containing silk scaffold, methods of stabilizing antibiotics in silk scaffolds, and methods for preventing or treating microbial contamination using the antibiotic-containing compositions. Various methods may be used to embed the antibiotic(s) into the silk fibroin-based compositions. The antibiotic-containing compositions of the invention are particular useful for stabilizing antibiotics, preventing bacterial infections, and for medical implants, tissue engineering, drug delivery systems, or other pharmaceutical or medical applications.WO 2010/141133 PCT/US2010/026190 1/10 / 4-Y -- -----0. G -- S- M icrospheres in Scaffold - Layered on Scaffold -v Emrbedded in Scaffold -- Layered on Siik M1Iat CO 20 40 60 so 100 120 14 0 16O0 18 Time (Hours) Figure 1 T 0 AS - C .4- -7-k 4y 0.2 --- Microspheres n Scaffold -- - Layered on Scaffold -v- Layered on Sik Mat - 7- Eimbedded in Scaffold 0 20 40 60 80 10C 120 140 160 180 Time (Hours) Figure 2 12605851.1
