Suh-Hang Juo,Ku-Chung Chen,I-Chung Hsieh,Ching-Yu Hu
申请号：
US13152520
公开号：
US08716256B2
申请日:
2011.06.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
There is provided a method of therapy of atherosclerosis, by providing microRNA let-7g, an analogue thereof or modified let-7g to organisms to inhibit the expression of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1), and the binding of LOX-1 and oxidized low-density lipoprotein (oxLDL), so as to block the pathogenesis of atherosclerosis. Also, a method of diagnosis of atherosclerosis comprises determining the levels of microRNA let-7g in serum or plasma samples of organisms, in which the levels of microRNA let-7g is estimated in individuals with atherosclerosis as compared to individuals without atherosclerosis.
