ARNAUD LE TIRAN,JAMES EDWARD PAUL DAVIDSON,JAMES BROOKE MURRAY,MIKLOS NYERGES,JANOS TATAI,I CHEN,DIDIER JEN - DURAND,IMRE FEJES,OLIVIER GENESTE,THIERRY LE DIGUARHER,JRME STARCK,JEAN BENOT - HENLIN,ANN
申请号：
ARP140102677
公开号：
AR096979A1
申请日:
2014.07.21
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Useful compounds in the treatment of apoptosis and cancer. Medicines. Claim 1: Compound of formula (1) wherein: A¹ and A² independently represent each other a hydrogen or halogen atom, a linear or branched C₁₋₆ polyhaloalkyl, a linear or branched C₁₋₆ alkyl group or a cycloalkyl group； T represents a hydrogen atom, a linear or branched C₁₋₆ alkyl optionally substituted with one to three halogen atoms, a C₁₋₄-NR¹R² alkyl group,O c83318324-r8310a, rental group c8332121；R¹ and R² independently represent each other a hydrogen atom or a linear or branched C₁₋₆ alkyl group, or R¹ and R² form with the nitrogen atom to which a heterocycloalkyl is attached； R³ represents a linear or branched C₁₋₆ alkyl, C₂₋₆ linear or branched alkenyl, C₂₋₆ linear or branched alkynyl, cycloalkyl, C o linear or branched C₁₋₆alkyl, heterocycloalkyl, aryl or heteroaryl group, it being understood that one or several carbon atoms of the above groups, or of their optional substituents, may (n) be deuterated (s)；R83088 represents an arilo, heteromorphic, cyclododecyl, or c8321s 83318326 linear or branched tar group, on the understanding that one or more carbon atoms or their substitutes in the above groups may have deuta (s)；R⁵ represents a hydrogen or halogen atom, a linear or branched C₁₋₆ alkyl group, or a linear or branched C₁₋₆ alkoxy group； R⁶ represents a hydrogen atom or a linear or branched C₁₋₆ alkyl group； Rᵃ,R74955,R758080 and r74966 represent r8311a and r8311a respectively,a halogen atom, a linear or branched C₁₋₆ alkoxy group, a hydroxy group, a linear or branched C₁₋₆ polyhaloalkyl group, a trifluoromethoxy group, -NR⁷R⁷,nitro, R⁷-CO-alquil C₀₋₆-,R8311811-co-nh-asphalt c8320331；No. 8311； No. 8311 - co-oquil c8320c83318326 -,No. 8311； No. 8311 - co - lease No. c83220 - 83316263-o -,R⁷-SO₂-NH-alquil C₀₋₆-,R⁷-NH-CO-NH-alquil C₀₋₆-,R⁷-O-CO-NH-alquil C₀₋₆-,a. A straight Gang, or a replacement for a couple (r7491r74955)；(Rᵇ, Rᶜ) or (Rᶜ, Rᵈ) together with the carbon atoms to which they are
