MCCONNELL, Russell E.,DOOLEY, Kevin P.,HARRISON, Rane A.,XU, Ke,HOUDE, Damian J.,HAUPT, Sonya,KULMAN, John D.,WILLIAMS, Douglas E.,YOUNISS, Madeleine
申请号：
AU2018367670
公开号：
AU2018367670A1
申请日:
2018.11.16
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention relates to methods of preparing a therapeutic exosome using proteins newly identified to be enriched in the lumen of exosomes. Specifically, the present invention provides methods of localizing a therapeutic peptide or protein in exosomes. The methods involve generation of lumen-engineered exosomes that include one or more of the exosome proteins at higher concentrations, a modification or a fragment of the exosome protein, or a fusion protein of the exosome protein and a therapeutic or cargo protein.
