A method of loading a composition into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition that is injected may include a therapeutic agent, and it includes a solvent and optionally an excipient. The solvent has a low boiling point, such as less than a temperature of 20° C., and the solution is injected at a condition of temperature and pressure such that the solution is a liquid or a supercritical fluid state.
