MCCONNELL, RUSSELL E.,DOOLEY, KEVIN P.,HARRISON, RANE A.,XU, KE,HOUDE, DAMIAN J.,HAUPT, SONYA,KULMAN, JOHN D.,WILLIAMS, DOUGLAS E.,YOUNISS, MADELEINE
申请号：
CA3082588
公开号：
CA3082588A1
申请日:
2018.11.16
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention relates to methods of preparing a therapeutic exosome using proteins newly identified to be enriched in the lumen of exosomes. Specifically, the present invention provides methods of localizing a therapeutic peptide or protein in exosomes. The methods involve generation of lumen-engineered exosomes that include one or more of the exosome proteins at higher concentrations, a modification or a fragment of the exosome protein, or a fusion protein of the exosome protein and a therapeutic or cargo protein.
