The invention involves agents from the alliance to RSPO, especially agents from the alliance to Rspo3, and methods of using agents to treat diseases such as cancer. The invention provides antibodies that specifically combine the activity of human protein rsp3 with that of beta ketamine. The invention provides a method preparation for regulating rsp3 activity of proteins and inhibiting tumor growth.La invencion se relaciona con agentes de union a RSPO, particularmente agentes de union a RSPO3 y metodos de uso de los agentes para tratar enfermedades tales como cancer. La invencion proporciona anticuerpos que unen especificamente proteinas RSPO3 humanas y modulan la actividad de beta-catenina. La invencion proporciona ademas metodos de uso de agentes que modulan la actividad de proteinas RSPO3 y que inhiben el crecimiento de tumores.
