The Invention relates to binding agents RSPO rspo3, particularly binding agents and Methods of use of the Agents for treating diseases such as cancer. The Invention provides Antibodies which specifically bind to Human rspo3 proteins and modulate the activity of beta Catenin.The Invention also provides Methods of using agents that modulate the activity of Proteins that rspo3 and inhibit the growth of tumors.La invencion se relaciona con agentes de union a RSPO, particularmente agentes de union a RSPO3 y metodos de uso de los agentes para tratar enfermedades tales como cancer. La invencion proporciona anticuerpos que unen especificamente proteinas RSPO3 humanas y modulan la actividad de beta-catenina. La invencion proporciona ademas metodos de uso de agentes que modulan la actividad de proteinas RSPO3 y que inhiben el crecimiento de tumores.
