The present invention relates to a pharmaceutical composition that contains a combination of a first antigen-binding molecule and a second antigen-binding molecule. The first antigen-binding molecule and the second antigen-binding molecule do not bind by covalent bonding. When mixed into a liquid, the pharmaceutical composition forms heterodimers more easily than homodimers. The present invention also relates to antigen-binding molecules, a treatment method, and a screening method that are related to the abovementioned combination.本發明是關於一種藥學組成物，含有第1抗原結合分子及第2抗原結合分子的組合，前述第1抗原結合分子及前述第2抗原結合分子未利用共價鍵而鍵結，並且於液中混合時，比起形成同型二聚體更易形成異二聚體。進而本發明是關於與該組合相關連的抗原結合分子、治療方法、及篩選方法。
